Adrenergic Receptors Modulate Motoneuron Excitability, Sensory Synaptic Transmission and Muscle Spasms After Chronic Spinal Cord Injury
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منابع مشابه
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
The brain stem provides most of the noradrenaline (NA) present in the spinal cord, which functions to both increase spinal motoneuron excitability and inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). NA increases motoneuron excitability by facilitating calcium-mediated persistent inward currents (Ca PICs) that are crucial for sustained motoneuron...
متن کاملMuscle Spasms After Chronic Spinal Cord Injury Excitability, Sensory Synaptic Transmission and Adrenergic Receptors Modulate Motoneuron
[PDF] [Full Text] [Abstract] , April , 2011; 105 (4): 1835-1849. J Neurophysiol Brian R. Noga, Dawn M. G. Johnson, Mirta I. Riesgo and Alberto Pinzon receptors in the thoraco-lumbar spinal cord 2b α or NE 1a α with NE Locomotor-activated neurons of the cat. II. Noradrenergic innervation and colocalization [PDF] [Full Text] [Abstract] , October , 2011; 106 (4): 1652-1661. J Neurophysiol Tany...
متن کاملAdrenergic receptors modulate motoneuron excitability , sensory synaptic 1 transmission and muscle spasms after chronic spinal cord injury
Adrenergic receptors modulate motoneuron excitability, sensory synaptic 1 transmission and muscle spasms after chronic spinal cord injury. 2 Rank MM, Murray KC, Stephens MJ, D’Amico J, Gorassini MA, and Bennett DJ 3 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada 4 5 6 Running Title: Adrenergic receptors modulate spasms. 7
متن کاملConstitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury.
In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents (CaPICs) without the ligands serotonin and norepinephrine below the injury. In this study we soug...
متن کاملRole of endogenous release of norepinephrine in muscle spasms after chronic spinal cord injury.
The recovery of persistent inward currents (PICs) and motoneuron excitability after chronic spinal cord transection is mediated, in part, by the development of supersensitivity to residual serotonin (5HT) below the lesion. The purpose of this paper is to investigate if, like 5HT, endogenous sources of norepinephrine (NE) facilitate motoneuron PICs after chronic spinal transection. Cutaneous-evo...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2011
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00775.2010